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Antibiotic resistance HGT

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Antibiotic resistance HGT program allows you to identify horizontal transfers of antibiotic resistance genes between bacteria. All the data are taken from ARDB - Antibiotic Resistance Genes Database.

You have to select an antibiotic, a corresponding antibiotic resistance gene and the list of species (at least 4). The program will infer a species tree (using the GenBank taxonomy) and a gene tree (using GenBank and accession numbers from ARDB). The gene tree sequences are aligned using MUSCLE and the gene tree is inferred using RAxML. The HGT-Detection algorithm (Boc et al. 2010) is then used to infer horizontal gene transfers.

This program was developed by Nail Amine Chabane, Sofiane Amir Reda Tighilt and Vladimir Makarenkov.

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Boc, A., Diallo, Alpha B. and Makarenkov, V. (2012), T-REX: a web server for inferring, validating and visualizing phylogenetic trees and networks, Nucleic Acids Research, 40(W1), W573-W579.

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